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Worried about announcement to MIL

2016.10.29 23:52 saunterasmas Worried about announcement to MIL

FTD here. We're at 11w today and have not announced to anyone. Our first scan is on Nov 7th and we are waiting to see if everything is fine before we tell people. We are not married, but have been in a wonderful relationship for 12 years now.
Both families love the other partner, and there is no conflict. We were over at IL (let's just use that for ease) house yesterday and MIL was doing her usual -3 very unsubtle mentions about grandchildren. I laughed inside at the time.
After we left I asked my partner if she was worried about anything announcing to our parents. She said the only thing that she is worried about is her mother calling the child a bastard. This surprised me, but may make sense. They are from Cathloic background, but not practicing. My partners grandmother is practicing, but she has never voiced disappointment in our living together and we get along great.
The possibility of the word coming out is real I guess, even if it is said in a joking manner. How do I/we handle this? Do I get angry? Do I firmly ask for her to move into the 21t century (which she is in most ways)?
Also as a side note, we are getting married at the end of the year, eloping and not telling anyone. We both know and feel it doesn't mean much at this stage, but it's really just a 'Why not?' thing now.
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2013.03.03 06:41 tabledresser [Table] IAmA: IAm Dr. Robin Carhart-Harris from Imperial College London I study the use of MDMA & Psilocybin mushrooms in the treatment of depression." AMA

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I am 43 years old and a chronic sufferer of "cluster" headaches. At one point, I was on 13 different pharmaceuticals (nothing narcotic, because those don't touch these headaches). I have "cultivated" a network of support that has allowed me to medicate with nothing more than magic mushrooms for the past 2 years. This is the only medication that has worked for me. I'm working full-time again and I no longer think about suicide on a daily basis. It has literally saved my life. My question is not medical, because I know this substance works. But I also know that my helpers are risking prison time by helping. Do you see any hope for legalization in the future? In terms of medicinal use, I really hope so. Glad you've been helped.
I think it's important to campaign and make people aware of cases like your own.
What do you use, if anything, to follow an MDMA treatment? I have heard of people taking 5-HTP to combat the serotonin depletion. Does this work? We didn't give anything. 5-HTP is a good idea though and in the future we'd test this i.e. see if one group given 5-HTP have less severe hangovers... It was a bit of an oversight not to have done this in the first place..
But seriously, mostly via word of mouth. It's not hard to recruit, that's for sure!
What are your thought's on the recreational use of psilocybin and MDMA? Be careful, read up and don't get yourself a criminal record.
Also, don't ever let recreational use become your life. It's the same with all drugs.
How would you explain the entities in a DMT experience on a neurobiological level? Just dream-like projections of the self? I think they're probably archetypal, humans are primed to see entities (our mothers eg) from a very early age. I just think it's the mind's internal models of what might be out there that become manifest and then confuse us into thinking they're actually 'out there'
I guess what I'm asking is, people have said that it kills massive amounts of brain cells or can cause you to develop schizophrenia, or cause you to be "burnt out". Is any of that true or possible? Or anything related. There's no known cell death with either drug but MDMA can damage serotonin cell fibres in large doses.
Irresponsible use of psilocybin runs the risk of paranoid experiences, so be very careful and treat all psychedelics with huge respect. They're not to be messed with.
Are you spiritual or religious at all? If not, do you think this type of research will give insights into where the idea of God or spirituality originated? I was brought up cathloic and attending church every sunday, sent to a catholic school, was an alter server.
I love the art of religion and I'm fond of it.
I'm a scientist and an atheist now though and I feel a bit sad every now about the lost magic that comes with atheism.
I feel wonder about the beauty of nature though. I can feel an overwhelming euphoria about the vast beauty of nature.
Plus, I'm fond of Buddhist ideas and used to meditate.
Sorry, last bit: yes, I feel like we're on the verge of major insights about the biological underpinnings of spiritual type experiences and how religious structure evolved from the spiritual experiences of pre-historic and ancient man.
I think it's great that researchers are exploring psilocybin mushrooms to help people struggling with addiction and/or depression. My question is, given the amazing results of the Marsh Chapel Experiment and the followup at Johns Hopkins University, how do you feel about psilocybin use among otherwise healthy individuals to achieve greater life satisfaction and wellbeing? Huxley had a kind of elitist view about this which I used to dislike but now sort of understand. He said you need to have the intellectual capacity to put the experience into a context. I sort of see what he meant. I think you at least need to be able to ground yourself after the experience.
All the benefits come from returning to normal waking consciousness and its that state we should celebrate. The psyche state is an incredibly useful holiday but we need to be mature in returning to normality because otherwise nothing would get done and society would be chaotic. Huxley wrote beautifully about this in DoP.
20 Years ago hallucinogenics were my drug of choice. With proper preparation: a place, a partner, a plan of play and no work the next day, I and my mates always had a lovely time. I credit my experience especially with Mushrooms with opening my mind to the interconnectedness of humanity. It made me a more compassionate person I think. I credit my LSD use with allowing me to re-qualify past events so that they took on a more objective and less emotional base in my mind. I was able to psychologically distance myself from some negative influences from my child hood. I resent the resistance to using these tools to help the soft science of psychology make in roads with PTSD and depression. Like anything that changes a person, controls must be put in place. What do you see as the most important control factor in your studies? I think it's really important that an academic working with these drugs respects their power. That sounds a bit grand but as soon as you start being complacent about the drugs, that's when negative events become more likely. I have to remind myself before each administration that the volunteer is about to embark on something remarkable and should be properly prepared for that.
When you were younger, was it your intent to work with psychedelics, or is it something that interested you after you began researching other fields? I had a strange experience when I was quite young which opened my eyes but then essentially forgot about it until I became very interested in psychology and specifically psychoanalysis and I learned that people believed in the 50s and 60s that LSD could allow access to difficult to access psychological material. That absolutely fascinated me.
It was my reading that inspired me. I didn't plan it but when I read stan grof's realms of the human consciousness, it was then that I knew what I wanted (and had) to do.
Hi :) thank you for taking the time to talk with us. 1. what are your thought's on Terence McKenna's stoned ape theory? (Link to www.youtube.com I'm not really familiar with the stoned ape theory, can you summarise?
Do you believe that using Psychedelics and MDMA (or MDMA analogues) recreationally, is something that responsible adults should be able to legally do? or do you see them as purely medicinal tools? 2) and also what is your opinion on the comparative Neurotoxcity in MDMA, BK-MDMA, and Alcohol? I think that there should be psychedelic centres where anyone, properly screened can sample the experience in the right kind of setting. These centres would be staffed my medical health professionals and people shouldn't be allowed to abuse the opportunity to have the experience. I think it would be problematic if psychedelics could be taken out of the clinic (like medicinal cannabis in the US eg) because without question you will get some disasters and it would mean a return to the 60s and the tarnishing of these drugs' name again.
After having tried them back in college all i can think is what if you have someone that has a "bad trip"? I personally never experienced that but was always in good spirits heading into it I can't imagine it would always go so well with someone who suffers from Depression. It will be very difficult for some patients, you're absolutely right. We have to be prepared for bad trips and we will prep the patients for difficult experiences. We'll ask them to reveal feelings of anxiety as soon as they feel them. We'll reassure them it's normal and even potentially useful to feel some anxiety and we'll reassure them that we're with them all the way and that they should explore sources of anxiety rather than try to flee them as it will be in the confrontation that the potential benefits will be greatest.
Do you think the UK government will change their drug classing system anytime soon? If not what do you predict will happen in the next couple years? With new research chemicals filling in the legal market with so little known about their long term effects. I think the next government, which will likely be labour will make some reforms yes.
Reform is inevitable but the Tories won't do it. The thing is, it's pretty likely the Tories will get a kicking at the next GE.
Can you give us a TLDR (too long didn't read/abstract) on WHAT Psilocybin and MDMA does to use that would help with these things? (Like, does it raise our serotonin or dopamine levels, or is it due to the reaction our body has with the drug that is what produces the results). Psilocybin stimulates serotonin receptors and the psychedelic effects appear to occur through the serotonin 2A receptor.
If it IS a serotonin/dopamine increase, have you tried the two in conjunction with Ginko Bilboa or other nootropics to increase or prolong the effects? MDMA increases levels of serotonin, noradrenaline and dopamine and doesn't really stimulate any receptors directly.
What made you want to study them? The idea that they could access hidden parts of the mind. What is more fascinating than that!
I’m not sure if this is the correct AMA to ask this question on, but I figured it’d be the best time to ask. Do psilocybin and/or MDMA pose any negative health risks when used? Yes. The risks around psilocybin are psychological mainly. If taken in the wrong environment or if you're in the wrong frame of mind without people around you who could look after you if you start getting anxious and/or paranoid, then there's the potential for a very difficult experience. It's extremely important that attention is paid to set and setting, or how you feel at the time and what kind of environment you're in. Physiologically, psilocybin is very safe. With this said, psilocybin may pose some significant mental health benefits however if taken in the right way with the right people around you. With MDMA, it's a little different. The experience is less psychologically challenging but more physiologically taxing. The serotonin low that follows an MDMA experience is a bit of a problem and if the drug's really over-used then there's a potential risk of causing some damage to the serotonin system - which could affect mood for example. The moderation message with MDMA is very important.
In higher doses people often report spiritual experiences, seeing other forms of themselves, interacting with other beings, and entering other "dimensions". Do you think there's something to that? Or in your opinion are these all just manifestations of the brain ? I think there is something in that but I think it can be explained psychologically eg with reference to Jungian theory and writings on the phenomenology of the mystical/spiritual experience. I don't think it's metaphysical however.
Yes, they are manifestations of the brain. There's no question imo. But I still think that is an absolutely amazing thing.
Do you think that research like this could actually lead to the introduction of these drugs as therapies if proven beneficial, or do you think mainstream societal fear of "drugs" as legitimate pharmaceuticals (and the pharmaceutical lobby) will deter its use? I think they will be developed as therapies.
What are your thoughts on microdosing? Say 5-10 micrograms of LSD every day for an extended period. Therapeutically?
I'm not sure, I'd worry about become a bit detached from reality.
Although, this is sub-psychedelic, so it's an interesting idea.
Personally I'm not convinced though but remain open-minded.
I have taken LSD once and Ayahuasca once, but I am fearful of experiencing psychedelics again because I think, that they are not well enough researched and they could lead to permanent damage (“going crazy” due to a “predisposition”). • The experiences caused by psilocybin are very similar to the ones of people suffering from schizophrenia and psychosis. Because of the plasticity of the brain, do you see a danger with regard to psychedelic experiences exercising the brain to become schizophrenic or psychotic (by forming some of the unwanted connections of those diseases)? I do think there's a potential danger of resulting psychoses, so people need to be very careful. I personally couldn't advocate recreational use because I only how how it should be done properly in a clinical setting.
• Does psilocybin cause vasoconstriction in certain parts of the brain? If so, can this lead to a collapse of capillaries and/or death of neurons in those regions at higher doses? Collapse of capillaries - there's no evidence.
I have heard anecdotal evidence for psilocybin as a possible reliever of migraines. Do you know of any research in this area? Thanks very much. Yes, Andrew Sewell is a name worth googling. It's a credible idea. A lot of migraine drugs are ergot derivatives a bit like LSD, plus classic psychedelics probably do have a potent effect of blood vessels.
I am a 27 year old male that currently suffers from depression and generalized anxiety disorder. I currently take paxil and smoke cannabis occasionally (medical card). Thanks for the message. Paroxetine will only attenuate the effects of mushrooms, so it won't be more intense or panic-laden with your current meds.
I have not consumed mushrooms since I have started paxil as I am hesitant given my reaction. Do you have any suggestions or thoughts on my situation? Thank you for your time! The last that if the shrooms work for you and you feel better for a good while, don't feel the need to re-dose, just be happy that you've found some relief and get on with enjoying the ups and downs of normal life. Good luck.
Can you tell us more about the troubles and walls you've had to deal with and get past to research illegal supplements like these? And to follow up, What laws/ political B.S. is the most detrimental to your work and advancing care and knowledge for your studies? Some MPs have taken a dislike and tried some personal attacks on my seniors. Ignorance is the main problem but the next generation of politicians will be less ignorant. People like David Nutt are so important for breaking taboos and tackling misinformation.
Q1.What biological function or advantage does the production of psilocybin bestow upon plants/fungi that produce it? Q2. Are there any receptor (serotonin 2a receptors?) that only bind with psychedelic compounds, and if so, for what biological or evolutionary reason do they exist? Maybe to stop sheep eating them. Liberty caps also look a bit like droppings and that's another deterrent. The best explanation is that it's to stop things hosting on them though. Doesn't stop humans though!
I personally am an advocate for drug law reform. With all they hype over medicinal marijuana in the US do you think psyches will be available in the same manner? Do you think they will ever become wholly legal? Train to become a psychiatrist if you seriously want to get into this research. It will make you much more appealing to people like me and my seniors. Psychiatrists are premium in this area.
I often feel psychedelics are my greatest passion in life. What kind of classes/subjects would you suggest that someone in college take if they wanted to study psychedelics? I think Psychs should only be taken in centres. I'd worry about a 'take-away' set-up. I think that would be problematic. There could be loads of these centres, they could define a city's culture eg, and they could be exactly where you'd want to have the experience. They could be out in the countryside eg - but always properly staffed by trained professionals.
How do these drugs interact with other anti-depressant drugs? Mainly SSRI's such as prozac? SSRIs attenuate the effects because they upregulate 5-HT2A receptors because of increased synaptic 5-HT.
How would you compare the effectiveness of psilocybin & mdma on depression and addiction compared to hoffman's lysergic acid diethylamide? Difficult to say.
Psilocybin for depression imo.
MDMA for PTSD.
And maybe psilocybin and LSD for addiction.
LSD is incredibly potent and addiction (esp to alcohol) is maybe the most stubborn psychiatric disorder of all, so LSD for addiction is worth a shot.
Dr. Carhart-Harris, if you could have any historical person work on the trials with you, who would you pick and why? Also, who do you pick to work with you, if you can already and why? I think Sidney Cohen was under-rated. He's my main hero from the 60s era.
I also like Huxley's poetic descriptions in DoP.
But, if I had to choose one, it would probably be Freud. an incredible mind.
How much is known about the damage caused by MDMA to serotonin receptors, and the potential for self-repair of those cells? There's no damage to serotonin receptors with MDMA but some potential damage to axonal fibers. Repair does happen it seems. Full repair seems to happen in most areas but there's some suggestion that some cortical regions may not show complete recovery. See Erritzoe et al. in Archives of Gen Psychiatry for this paper.
I was recently watching a documentary on nat geo on hallucinogenics. A man (~52yrs) has been suffering cluster headaches for years and discovered that consuming psilocybin mushrooms every two months eliminates the headaches. My question is; how does psilocybin do this? Maybe via constricting blood vessels - the research needs to be done.
About 12,000 years ago, further climate changes removed the mushroom from the human diet, resulting in a new set of profound changes in our species as we reverted to pre-mushroomed and frankly brutal primate social structures that had been modified and/or repressed by frequent consumption of psilocybin. Question: Do you have opinion on psilocybin's influence in the brains of the early humans? I think early humans probably had a trippy-kind of cognition anyway and if they took psychs it just made things even weirder.
Where would you like to see this line of research go over the next 20 years, and how would you like to see it applied? Next 20s: careful research, accumulating the evidence, changing the face of psychiatry for the better. Developing the insights on offer from psychedelics in a evidence-based framework.
Also, what do you think about Dr Rick Strassman's famous DMT study? Strassman's study was very pioneering. I'm not sure what happened to Strassman as a scientist though, he seemed to disappear from the scene. There's probably something I don't know.
What is the most common similarity in experiences reported by people who take psilocybin? Geometric hallucinations and odd bodily sensations (tingling) as they come up.
At least at our doses.
I was diagnosed with depression 2 years ago, and have tried different avenues of treatment, but was curious as to what progress (if any) MDMA / Psylocybin have on depression and long term treatment options avalible! :) It's a boring message but I do really think it's all to do with the synergy between the drug action and the care structure around the experience.
What's your opinion on Holotropic Breathwork? I'm pretty ignorant but it probably causes brain states similar to as occurs with LSD. The Hypoxia may simulate this state.
What is your favorite dinosaur? T-rex is a bad mother.
How does a general day at the lab go? What do you spend most of your time doing? What are the people around you like? Regulatory stuff! :-(
Plus a bit of writing, which I love.
What is it exactly about psychedelics that make them so non-toxic despite having profound effects on brain chemistry? Why can you take such large quanitites of LSD or psilocybin and suffer comparatively little harm than other psychoactive compounds like cocaine? Probably because they a lot like serotonin.
It's a bit of a myth that you can take large quantities of LSD though. If you take too much it will poison you. LSD is very potent though so you only take tiny doses and yet have a profound experience.
Will you be joining us at the next ICPR in Amsterdam? Your talk this year was great. Sure, if I can.
Do you know anything about the research chemical 2C-i-NBOMe aka 25i-NBOMe? If so do you believe that these may also have therapeutic benefits? It's been said that it has similar effects to that of LSD but I personally cannot vouch for that through personal use or research. I don't know sorry.
Were you involved in that study that came out about 6 months ago (may have been more) that found users of psilocybin to have a permanent improvement in empathy over those who had never? Nope, wasn't me sorry. Maybe Roland Griffiths?
What do you think of the legality of the drugs you study? Big topic but I think psilocybin as class A and alcohol as legal is ridiculous. It'd almost be funny if it wasn't so harmful and serious.
What would you say has been the most exciting finding/result/outcome that you have seen thus far? The most exciting result was the decreases in default mode network activity after psilocybin. This network is linked to the sense of self and so it makes a lot of sense in the context of ego-dissolution under psychedelics.
Any realistic data on human LD50 for MDMA? I've seen different sources range from 1,500 mg to 7,000 mg. I recall reading one story about an individual who was eating over 2,000 mg a day. He collapsed eventually. 2 grams a day! I'm not surprised. It's difficult to do the camprisons but high doses of MDMA are generally a very bad idea is any context.
From what I gather your work has been with unipolar depression. Any thoughts/knowledge to share about bipolar depression and substances like this? Very difficult. I worry about inducing mania.
How has the topic of synchonicity been expressed by your research subjects? Jung's idea? Or neural synchrony?
What about the afterlife? Jung's idea is a bit wishy-washy imo - it's an example of magical thinking. You want to believe the incredible because it excites you.
Are your family very proud and understanding of what you are doing? Do you have scientists in your background? What has been the biggest difficulty when talking about your trials and media work to your loved ones? Do they have any concerns? My family are proud of the academic success and smile about the subject matter. They're not big into drugs but they're proud and have been incredibly supportive.
My Mum's much more clued up about drugs since I've become a scientist.
How important is it to develop novel therapeutic techniques, or even environments, for use with psychedelics? How hard will it be to quantify the therapeutic value, or dangers, of psychedelics in relation to different therapies and therapeutic environments? Comparing psychs against other meds and treatments is the next stage. The focus right now is on small pilot studies to demonstrate efficacy.
What seems to be the most profound effect of psilocybin/Psilocin and other Psychadelics? Ego-dissolution.
Everything profound follows from knocking this 'reducing-valve' out of the way.
Hello Dr Carhart-Harris, thank you for doing this AMA. I've experimented with MDMA a small number of times and greatly enjoyed it. More specifically I enjoyed the prolonged feeling of positivity that followed me for a few weeks, only to have it give way to my incessant pessimism. With your experience Doctor, what sort of advice would you offer to help the "lessons learned" stick? MDMA might not be the right compound to treat depression. The serotonin low post-use may be problematic.
Psilocybin has more potential for depression imo but the experience is much more difficult and not always pleasant like MDMA.
When do you foresee governments not shutting down full research on illegal substances? They haven't shut it down now. I'm hoping they'll relax the schedule one on psilocybin within 10 years though. Once their medicinal value is proven, they'll have to. Expect a bit of press about this from David Nutt within the next 6 months. You heard it here first.
What do we currently know [and what research have you performed] about the interactions between Psilocybin and antidepressants? We could go through the gambit of the various forms but my curiosity is focused on Norepinephrine-dopamine reuptake inhibitors and Psilocybin. Good question. There's only anecdotal evidence but it suggests certain ADs attenuate the effects of psychs.
Na/DARIs won't affect psilocybin so much would be my guess. SSRIs more so.
Do animals actively or accidentaly eat fungi containing psilocybin? How does it affect them? Some might, I don't know. I think it's probably a natural deterrent
Do you take your research subjects off their medication before administering psilocybin? Do you have any knowledge of interactions between these substances? We won't actual take our patients off their meds and it's easy to have a big relapse. The fluoxetine will only attenuate the effects, so there's no risk of a negative interaction.
Thank you for doing this AMA. Is there any evidence that you know of that frequent (or infrequent) psilocybin or LSD use can cause long-term brain damage or other physiological issues? Thanks. There's no evidence for that.
Do you think that even unknowingly some drugs (specifically MDMA) have a therapy type effect even when used recreationally? I am used to doing this drug and I feel that my relationship with people has been much better, especially to close friends whom I have spent nights with on the drug. Do you think that the overall vibe from parties and raves (unless your life revolves around these activities) which MDMA is mostly known for, good for building strong relationships and character? Thanks. Yes, I do.
A lot of recreational users are incredibly clued up
How do you feel about LSD? Fascinating compound I'm very excited about studying in the next few months (hopefully)
What are some of the most profound ideas you've discovered while on mushrooms? also they say mdma takes "ice cream scoops" out of your brain, being a frequent user id like to hear that this is indeed false :) Ice scream scoops is complete nonsense. There may be some damage of fine serotonin axons but its dose dependent and never been established directly in humans.
I know the law isn't your expertise but would you support decriminalization of MDMA to be able to provide safer and more accurate doses (not cut etc)? Maybe, I'm not sure. You're right, policy is more David Nutt's domain.
A safer MDMA would be nice and club testing is a good idea.
What are your thoughts on the latest ketamine studies and it's effect on cell repair? Edit: here is an article about the study for those who are interested Link to www.theatlantic.com. Interesting but I think classic psychs have more potential.
What do you think is going to be legalized/decriminalised in US during the next 10 years? Next 10 years in the US...
I'm not sure to be honest...
Sorry.
Hi Dr. Carhart-Harris. I read about experimental trials of patients with PTSD being treated with MDMA and it helping them a lot. Is this in a similar vein to what you are doing with MDMA and depression? We're not doing MDMA depression research sorry. We don't do any patient studies with MDMA yet but they do in the US as you say. Dr Ben Sessa is trying to do a MDMA-PTSD in the UK and I hope he's successful.
Is it true that in England cadbury creme eggs are sold year round? Almost! Trippy huh!
Hello! I am a junior level student in college studying biochemistry, and I am very interested in neuropsychopharmacology/neurochemistry. How would you suggest entering into these professions? Do you find your job rewarding? And what are some of the new advancements in the field that you are excited about? Do a medical degree. It's the best way in, trust me.
Hello Dr. Carhart-Harris, My question regards psilocybin's possible treatment of cluster headaches. My mother suffers from these and she's tried various methods of therapy, all to no avail. I hate to see her when she's in such a painful state, as she says that the entire right side of her body above her chest is writhing in pain. I've read some literature that says that psilocybin has been able to treat cluster headaches and, in some cases, even stop them from recurring completely. What are your thoughts on the subject? I think it can be useful but be careful, she'd need to be prepared for a very strange experience.
How do you find your subjects? Word of mouth mainly.
When administering psychoactive compounds for tests in a lab setting, how do you determine what constitutes a "safe" dosage for your subjects? Also, in administering psilocybin, do your subjects actually eat raw mushrooms or take it in a refined form like a tincture or pill? Previous literature and careful dose-finding.
Last updated: 2013-03-07 05:27 UTC
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